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pentobarbital will decrease the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Double brexpiprazole dose over one-2 weeks if administered with a powerful CYP3A4 inducer.Contraindicated (1)pentobarbital will minimize the level or effect of cariprazine by influencing hepatic